Body mass index may be the major determining factor of plasma cholesterol values

Mehmet Rami Helvaci (1)
Mustafa Yaprak (1)
Atilla Yalcin (1)
Orhan Ekrem Muftuoglu (1)
Abdulrazak Abyad (2)
Lesley Pocock (3)

(1) Specialist of Internal Medicine, MD
(2) Middle-East Academy for Medicine of Aging, MD
(3) medi-WORLD International

Corresponding author:
Prof Dr Mehmet Rami Helvaci,
ALANYA, Antalya, TurkeyPhone: 00-90-506-4708759
Email: mramihelvaci@hotmail.com

Received: December 2020; Accepted: January 2021; Published: February 1, 2021
Citation: Mehmet Rami Helvaci et al. Body mass index may be the major determining factor of plasma cholesterol values. Middle East Journal of Nursing 2021; 15(1): 18-24.DOI: 10.5742/MEJN2021.93798

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ABSTRACT

Background: We tried to understand possible effects of sickle cell diseases (SCD) on metabolic parameters including cholesterol values in the plasma.

Methods: All patients with the SCD and age and gender-matched control cases were included into the study.

Results: We studied 363 patients with the SCD (194 males) and 255 control cases (136 males), totally. Mean ages of the SCD patients were similar in males and females (31.1 versus 31.0 years, respectively, p>0.05). Although the body weight and body mass index (BMI) were significantly suppressed in the SCD patients (59.9 versus 71.5 kg and 21.9 versus 25.6 kg/m2, respectively, p= 0.000 for both), the body heights were similar in both groups (164.9 versus 167.0 cm, p>0.05). Parallel to the suppressed mean body weight and BMI, fasting plasma glucose (92.8 versus 97.6 mg/dL, p= 0.005), total cholesterol (TC) (121.4 versus 165.0 mg/dL, p= 0.000), low density lipoproteins (LDL) (70.4 versus 102.4 mg/dL, p= 0.000), and high density lipoproteins (HDL) (26.0 versus 39.6 mg/dL, p= 0.000) values were all suppressed in the SCDpatients, significantly. Similarly, both systolic (115.2 versus 122.6 mmHg, p= 0.000) and diastolic blood pressure (73.0 versus 86.6 mmHg, p= 0.000) were also suppressed in them, significantly. Interestingly, only the plasma triglycerides were increased in the SCD patients (129.4 versus 117.3 mg/dL, p= 0.000), significantly. Similarly, mean alanine aminotransferase value was not suppressed in them, too (27.4 versus 27.3 U/L, p>0.05).

Conclusion: The BMI may be the major determining factor of TC, LDL, and HDL values in the plasma.

Key words: Body mass index, total cholesterol, low density lipoproteins, high density lipoproteins, triglycerides, metabolic syndrome, sickle cell diseases